BeneSpore™ BV379: A Next‑Generation Probiotic for Functional Nutrition

Functional nutrition continues to evolve beyond traditional supplements, driven by consumer interest in gut health, digestive comfort, and ingredients that fit seamlessly into everyday routines. As this category expands into foods and beverages designed for daily use, one challenge remains consistent: delivering probiotics that are both scientifically substantiated and compatible with real‑world manufacturing conditions. BeneSpore™ Bacillus velezensis BV379 represents a new generation of probiotic ingredients developed with these realities in mind.

Rethinking Probiotics for Modern Functional Nutrition

Historically, many probiotics used in functional nutrition have been limited by strain sensitivity to manufacturing methods, including heat and acidity. These constraints often restrict product formats or require cold storage, encapsulation, or over‑formulation to maintain viability. As functional nutrition moves toward convenient, shelf‑stable products—such as protein powders, functional foods, and gummies—durability has become just as important as efficacy.

Spore‑forming probiotics offer a fundamentally different approach. By forming protective spores, certain Bacillus strains can withstand harsh processing environments, long storage periods, and gastrointestinal transit without the need for refrigeration or complex delivery systems.

What Makes BeneSpore™ BV379 Different

BeneSpore™ BV379 is a spore‑forming Bacillus velezensis strain developed specifically for functional nutrition applications. Its spore structure allows it to maintain stability across a range of processing and storage conditions commonly encountered in foods, beverages, and dietary supplements. This enables consistent delivery of live colony‑forming units (CFUs) in finished products intended for daily consumption.

Beyond formulation performance, BeneSpore™ BV379 is made in the US and is the only Bacillus velezensis strain on the market with FDA no objection letter for GRAS. With 3-year shelf life and ambient storage requirements, BeneSpore™ is an excellent choice of probiotic from application, scientific evidence and supply chain perspectives.

Enabling Broader Functional Nutrition Innovation

IBy removing traditional probiotic constraints, spore‑forming strains like BV379 allow functional nutrition to expand into formats that align with modern lifestyles—without sacrificing scientific rigor or product reliability. The stability and versatility of BeneSpore™ BV379 open opportunities across multiple functional nutrition categories, including:

• Powdered shakes
• Ready‑to‑mix food formats, such as baking mixes
• Cookies, muffins and other baked goods
• Ready-to-eat snacks and cereals, such as extruded products
• Gummies and confectionary
• Tea and coffee

Clinically Studied Digestive Comfort

With increased consumer awareness of functional health products comes a greater requirement for clinical substantiation. BeneSpore™ BV379 has been evaluated in a randomized, double‑blind, placebo‑controlled clinical trial in healthy adults. Daily supplementation with BV379 was associated with a higher proportion of participants reporting improvements in abdominal bloating compared to placebo, without disrupting the overall composition of the gut microbiota.

Bloating is a common consumer complaint. Almost half of American adults experience bloating at least once week, but a small proportion seek medical advice, preferring to seek solutions themselves. Different athletic populations also report gastrointestinal discomfort, with 30-90% experience issues.