What is MFGM?
MFGM (Milk Fat Globule Membrane) originates from secretion of milk fat in the maternal lactating cell. Milk fat globules are surrounded by a double-layered phospholipid membrane comprising bioactive components. High in protein content, MFGM ingredients come as a whey protein concentrate, rich in several bioactive components including IgG, MFGM proteins, lactoferrin and phospholipids (including sphingomyelin and gangliosides). These components have numerous health benefits for not just the infant, but possibly also for adults.
What are MFGM’S benefits, and have they been proven?
INFANT NUTRITION
There are three key areas for infant nutrition that milk fat globule membrane supports:
- Cognitive function
- Gut health
- Immune support
Cognitive function
Infants fed MFGM-supplemented formula from 2 months to 6 months of age performed significantly better in cognitive tests at 12m than infants fed standard formula. MFGM-supplemented infants did not differ from breastfed infants. This indicates that supplementing formula with MFGM really does allow a closer match to the benefits of breastmilk.
gut health
MFGM diet enrichment enhances gastrointestinal wellness in infants. MFGM supplementation for 6 months in 6-11-month-old infants reduced incidence of bloody diarrhoea and a tendency for less diarrhoea overall (Zavaletta et al, 2011). These results were echoed in another study that found supplementation in 8-24-month-old toddlers reduced the duration of rotavirus (Poppitt et al, 2014).
Supporting infant’s natural defense
MFGM-supplemented formula also showed a reduced incidence of acute otitis media (ear infection) and subsequently, less use of pharmaceuticals in the form of antipyretics, in infants in Sweden (Timby et al, 2015)
ADULT NUTRITION
Cognitive function
Phospholipids are a key component of the brain and important for normal brain development and functioning. The phospholipid profile of MFGM is like that of the human brain (see figure below). There is some limited literature showing a benefit of these phospholipids on working memory, cognitive performance, and stress management in adults.
Evidence around benefits outside of infant nutrition is building. For example, Hellhamer et al (2010) reported that, compared to placebo-exposed individuals, there was a tendency for shorter reaction times in the working memory task in those given milk phospholipids (PL), suggesting better performance. The PL-treated subjects with a higher stress load also showed a blunted psychological stress response.
In another study, Schubert et al (2011) found that supplementation with phospholipids may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments.
The benefits of milk phospholipids for cognitive function have also been demonstrated in children (Veereman-Wauters et al, 2012).
Gut Health
MFGM has been shown to be beneficial for infants by reducing the incidence of diarrhea and protecting against bloody stools. It is thought that the molecules act as a decoy for pathogens in the gut, thus the pathogens bind to MFGM instead of the gut wall.
Immune Function
Some of the bioactive compounds found in MFGM, including IgG and lactoferrin, are thought to have immune-promoting and anti-inflammatory functions [utilize lactoferrin info from lactoferrin-rich 80].
What applications does MFGM work in?
MFGM works well across applications, including RTM powdered shakes, RTD ready-to-drink, bars, cookies and many more.