The Rise of Next-Generation Probiotics
Probiotics have long been associated with beneficial bacteria like Lactobacillus and Bifidobacterium, but science is now uncovering new strains that offer unique advantages for gut health. One of the most exciting discoveries in this space is Bacillus velezensis, a spore-forming bacterium that thrives in challenging environments and delivers robust benefits for digestion, nutrient absorption and gut comfort. Unlike traditional probiotics, which can be sensitive to heat and stomach acid, Bacillus velezensis is remarkably resilient, making it an ideal candidate for health supplements and functional foods.
The name Bacillus velezensis traces back to its initial isolation near Vélez-Málaga, a coastal region in Spain known for its rich agricultural soils. This bacterium belongs to the Bacillus genus, a group of hardy microorganisms recognized for their ability to form endospores—protective shells that allow survival under extreme conditions. These spores act like biological time capsules, preserving the bacterium’s viability through heat, pressure, and acidic environments. This means supplements and foods containing Bacillus velezensis can withstand manufacturing processes and storage while still maintaining potency. Once ingested, the spores germinate in the intestines, where they help break down complex nutrients, produce enzymes, and support a balanced microbiome.
Research has shown that one unique strain of Bacillus velezensis, Benespore™ BV379, may play a key role in enhancing digestive efficiency. It was shown to produce digestive enzymes that are key for digestion of proteins, carbohydrates and fiber, thus potentially improving nutrient absorption. Additionally, it helps maintain microbial balance by inhibiting harmful bacteria and supporting beneficial species. It may have been these mechanisms that led to the findings in a recently published clinical trial. The study, published in Journal of the American Nutrition Association (2025), demonstrated that supplementation with Bacillus velezensis significantly reduced bloating in participants, highlighting its potential to address one of the most common digestive discomforts, especially in those using GLP-1 receptor agonists. For individuals seeking a probiotic that goes beyond basic gut support, Benespore™ BV379 offers a powerful, science-backed solution.
This unique strain has eluded human nutrition products – until now. With both clinical backing and the regulatory greenlight, Actus Nutrition offers Benespore™ BV379; the first and only FDA GRAS (no objection letter) Bacillus velezensis on the market. Demonstrated to have functionality and stability across both supplements and functional food applications, as well as a high concentration of 100bn CFU/g, Benespore™ BV379 is ready to match both customer and product development needs.
As interest in gut health continues to grow, Benespore™ Bacillus velezensis BV379 represents the next frontier in probiotic technology. Its resilience, multifunctional benefits, and natural origins make it a standout choice for supplement and functional food formulations aimed at digestive health and nutrient optimization. With ongoing research and increasing consumer awareness, this spore-forming probiotic is poised to become a staple in advanced gut health solutions. If you’re looking for a probiotic that combines durability with efficacy, Benespore™ Bacillus velezensis BV379 may be the breakthrough you’ve been waiting for.